Cymbalta is the brand name of duloxetine. It is used for the treatment of major depression and anxiety disorders. It is also used to treat pain from diabetic neuropathy and fibromyalgia. Cymbalta is available in extended-release capsules in strengths of 20 mg, 30 mg, or 60 mg. Effexor is the brand name of venlafaxine. It is used for the treatment of major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder.
Regular Effexor has been discontinued; however, Effexor XR tablets are available in strengths of But they are not the same drug. In addition to treating major depression and anxiety, Cymbalta is also FDA approved to treat certain types of nerve pain. On the other hand, Effexor is FDA approved to treat panic attacks and social anxiety. The better antidepressant depends on the condition being treated and other medications a person may be taking.
Venlafaxine may be a more effective short-term treatment option for depression. However, it may have a lower tolerability than Cymbalta in terms of side effects, such as sexual dysfunction. No conclusive studies have shown that Cymbalta or Effexor may be safe during pregnancy. An antidepressant should only be used during pregnancy if the benefits outweigh the potential risks. In some cases, Cymbalta or Effexor may need to be used to control symptoms of depression during pregnancy.
Consult a healthcare provider for medical advice before using Cymbalta or Effexor while pregnant. Alcohol in moderation is likely safe while taking Cymbalta or Effexor.
However, drinking alcohol while starting treatment with Cymbalta or Effexor may lead to increased dizziness or drowsiness. It may be advised to discontinue drinking alcohol until it has been a few days after starting treatment. There is no evidence that Effexor directly affects memory. Effexor XR has been known to cause hyponatremia, or low sodium levels in the blood, especially if diuretics are also being taken.
Signs and symptoms of hyponatremia include headache, confusion, and memory impairment. Your doctor may recommend stopping Effexor XR until the hyponatremia resolves. Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor SNRI.
Talk to a healthcare provider about potential antidepressant treatment options for you. The dose of Effexor should be slowly tapered to help prevent serious withdrawal symptoms.
Abrupt discontinuation of Effexor can lead to symptoms like nausea, dizziness, vomiting, nightmares, irritability, and headaches. Effexor withdrawal symptoms may also include paresthesias, or tingling sensations on the skin. Skip to main content Search for a topic or drug. Cymbalta vs. Effexor: Differences, similarities, and which is better for you. By Gerardo Sison, Pharm. Updated on May. The primary measure of efficacy was depressive symptoms severity.
The ITT efficacy patient sample consisted of 46 patients. No statistically significant difference emerged between the two groups at any post-baseline assessment, neither on mean scores of rating scales nor on qualitative efficacy measures. Although the dosage varies, a typical dose is 20 mg once a day. Prozac may be used in adults for all of the indications listed in the chart below.
Prozac can also be used in children over 8 years old for depression or over 7 years old for OCD. Cymbalta is indicated for major depressive disorder, diabetic peripheral neuropathic pain, and chronic musculoskeletal pain in adults. It can also be used for generalized anxiety disorder in adults as well as children ages 7 years and older and for fibromyalgia in adults and adolescents 13 years and older.
Cymbalta is not approved for use in children for depression, diabetic peripheral neuropathic pain, or chronic musculoskeletal pain. Prozac is indicated for major depression and obsessive-compulsive disorder OCD in children, adolescents, and adults. Prozac can also treat bulimia nervosa, premenstrual dysphoric disorder, and panic disorder. Prozac is not approved for use in children under 7 years old. Note: Symbyax is a combination drug that contains fluoxetine, the ingredient in Prozac, along with another medication called olanzapine.
Symbyax can treat depressive episodes associated with bipolar I disorder or treatment-resistant depression. Sometimes doctors prescribe these drugs off-label for other uses than what they are indicated. One study reviewed many studies comparing Cymbalta, Prozac, and another medication called Effexor, to placebo.
Cymbalta and Prozac were found to be similar in efficacy and safety for patients with depression. The diagnosis is an essential factor in deciding which medication will be more appropriate.
For example, if the indication is depression, either Prozac or Cymbalta may be an appropriate option. And if the diagnosis is fibromyalgia, Cymbalta is more appropriate because it is indicated for fibromyalgia, while Prozac is not. Your healthcare provider can determine which drug is more appropriate for you, taking into account your diagnosis, medical history, and other medical conditions, along with any medications you take that could interact with Cymbalta or Prozac.
Most insurance and Medicare Part D prescription plans cover Cymbalta or Prozac—choosing the generic form will result in significant cost savings. The brand-name products have a much higher copay or may not be covered at all.
The most common side effects of Cymbalta are nausea, headaches, sleepiness, appetite loss, constipation, dry mouth, and dizziness. The most common side effects of Prozac are headache, nausea, drowsiness, insomnia, appetite loss, sexual side effects, and nervousness or anxiety.
When you fill or refill your Cymbalta or Prozac prescription, you will receive a medication guide that discusses side effects, warnings, and other important information about your medication. This is not a full list of adverse effects. Other, serious side effects may occur. Consult your healthcare provider for a complete list of side effects.
The combination may increase the risk of serotonin syndrome , a life-threatening medical emergency due to excess serotonin. Triptans, which are migraine medications, such as Imitrex sumatriptan , and other antidepressants, should not be used in combination with Cymbalta or Prozac due to the risk of serotonin syndrome.
Also, the cough suppressant dextromethorphan, found in Robitussin-DM and many cough and cold products, should be avoided as it can also cause serotonin syndrome when combined with Cymbalta or Prozac.
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