Take the remaining doses for the day at evenly spaced times at least 4 hours apart. DO NOT take 2 doses at once. You should not take more than your prescribed dose and doing so may increase your risk of having a seizure. For bupropion XL, do not take an extra tablet to make up for the dose you forgot. Wait and take your next dose at your regular time the next day. Avoid drinking alcohol or using illegal drugs while you are taking bupropion because the beneficial effects of the medication may be decreased and the risk of seizures may be increased.
If you are dependent on drugs or alcohol and would like to stop, consult your healthcare provider for help. Abruptly stopping these substances can result in a seizure, especially when taking bupropion. If an overdose occurs, call your doctor or You may need urgent medical care. You may also contact the poison control center at Headache, weight loss, dry mouth, trouble sleeping insomnia , nausea, dizziness, constipation, fast heartbeat, and sore throat.
These will often improve over the first week or two as you continue to take the medication. Unlike many antidepressants, bupropion does not commonly cause sexual side effects and may be selected as an alternative treatment when antidepressant-induced sexual side effects are problematic. Sexual side effects include such problems as difficulty achieving orgasm or ejaculatory delay.
In general the risk of seizures due to bupropion is low. The risk of having a seizure increases with higher than recommended doses of bupropion, a history of seizures or head injury, tumor in the brain, severe liver disease, an eating disorder, alcohol or drug dependence, or taking other drugs that can also increase your risk of having a seizure.
There is a low risk of cardiovascular adverse events associated with stimulating agents, including bupropion. This risk increases if you have heart disease, high blood pressure, previous heart attack, or irregular heartbeat, or when used with transdermal nicotine replacement products. In these cases, a thorough cardiovascular evaluation is recommended before starting this medicine. To date, there are no known problems associated with long term use of bupropion.
It is a safe and effective medication when used as directed. Bupropion should not be taken with or within two weeks of taking monoamine oxidase inhibitors MAOIs. There are several products with the active ingredient bupropion. Do not take more than one product that contains bupropion since this may increase your risk of having a seizure.
Certain medications may increase your risk of having a seizure when combined with bupropion. These include other antidepressants, antipsychotics, theophylline, isoniazid, tramadol, stimulants, steroids, hypoglycemic agents including insulin , certain antibiotics e.
These medications can change the way your body reacts to bupropion. Bupropion can change the way your body reacts to these medications. Sleep, energy, or appetite may show some improvement within the first weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.
Depressed mood and lack of interest in actiities may need up to weeks to fully improve. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents and young adults when compared to placebo.
Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults ages 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
Last Updated: January If you need to stop taking Wellbutrin, your doctor will guide you in gradually tapering off of it. Everything feels more challenging when you're dealing with depression.
Get our free guide when you sign up for our newsletter. Wellbutrin bupropion hydrochloride tablets. Updated October Bupropion for attention deficit hyperactivity disorder ADHD in adults. Cochrane Database Syst Rev. Wellbutrin SR bupropion hydrochloride sustained-release tablets. Wellbutrin XL bupropion hydrochloride extended-release tablets. Updated July College of Psychiatric and Neurologic Pharmacists. Bupropion Wellbutrin.
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I Accept Show Purposes. Table of Contents View All. Table of Contents. Before Taking. Side Effects. The 5 Major Classes of Antidepressants. Was this page helpful? Thanks for your feedback! Sign Up. What are your concerns? Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles.
Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Related Articles. Cipralex for Depression. For depression, a typical starting dosage of bupropion is mg to mg per day, taken either as mg tablets taken twice per day or a single mg extended-release bupropion tablet taken in the morning.
The maximum dosage of bupropion for depression is mg to mg per day. After three to four days, you may need to adjust your dosage of bupropion. Follow the dosage instructions provided by your healthcare provider to make sure you take the right amount of bupropion.
For smoking cessation, a typical starting dosage is one mg extended-release tablet per day for the first three days, followed by a dosage of mg per day, taken as two tablets taken at least eight hours apart, from day four. Based on your symptoms, health history, response to the medication and several other factors, your healthcare provider may adjust your dosage of bupropion over time.
Like all antidepressants, bupropion can cause certain side effects. Most of the side effects that can occur with bupropion are minor and temporary. However, there are also several potentially severe side effects that you should be aware of before using this medication.
Some of the common side effects of bupropion include:. Many of these side effects may be mild and often disappear over the course of several days or weeks. In general, bupropion is less likely to cause sexual dysfunction than other commonly prescribed antidepressants, such as SSRIs and tricyclic antidepressants. Like other antidepressants, bupropion may cause serious side effects.
These side effects occur in a small percentage of bupropion users. Serious side effects of bupropion include:. Mental health issues, such as panic attacks, changes in mood, impulsive behavior and worsened depression or anxiety.
Bupropion may contribute to hypertension high blood pressure. If you have high blood pressure or a history of cardiovascular issues, make sure you inform your healthcare provider before using bupropion.
Though rare, depending on dosage, anywhere from. Conditions that may increase your seizure risk include:. Use of other drugs that may affect your seizure susceptibility, such as other antidepressants, antipsychotics, systemic corticosteroids or theophylline. Bupropion may also not be a suitable treatment for people with liver or kidney issues, diabetes or certain mental health conditions such as bipolar disorder.
This warning is found on bupropion medications used for treating depression — bupropion smoking cessation aids do not carry the same warning. Studies do not show that this risk occurs in people aged 24 and older.
Bupropion can interact with other medications, including over-the-counter medications, herbal products and health supplements. These interactions may increase the amount of bupropion in your body or make the medication less effective. In some cases, the use of bupropion can cause dangerous interactions with other medications. Dangerous interactions can occur when bupropion is used with monoamine oxidase inhibitors MAOIs — another type of antidepressant medication. If you have used an MAOI medication, such as phenelzine, isocarboxazid, tranylcypromine, selegiline or others, you must inform your healthcare provider before being prescribed bupropion.
Make sure to tell your healthcare provider if you currently use or have recently used any other medications to treat depression.
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